Muhammad Irfanullah Siddiqui
Umm Al Qura University Al Abidia,KSA
Title: Comparison of Allopathic and Herbal Medicine For The Treatment Of Entamoeba Histolytica; A Double Blind Clinical Trial
Biography
Biography: Muhammad Irfanullah Siddiqui
Abstract
Objective: This parallel, randomized, double blind clinical trial was designed to compare allopathic drugs MDF (a combination of metronidazole + diloxanide furoate) with Endemali (herbal product) for therapeutic cure rate and side effects in order to find out the most suitable drug for this killer disease.
Methodology: This double blind randomized clinical trial was conducted in two areas of Karachi, Pakistan after approval from ethical committee of Hamdard University. All those confirmed for E. histolytica were included in the study. One hundred and seventy one patients selected for study randomly allocated to two arms of 86 and 85 for allopathic and herbal treatment respectively. However 78 in allopathic and 75 in herbal group completed the study. Main outcome variable was treatment success or failure. Secondary outcome measures included side effects, and association with age and sex.
Results: No significant difference was observed in the socio economic and demographic variables at the baseline. No significant difference was found between the cure rate of MDF and Endemali; hence both drugs were equally effective in treating amoebiasis. Significant differences were reported for the side effects observed among the two groups and the price. The failure rate for the two drugs was 28.7%.
Conclusion: It is concluded that both Endemali and MDF are equally effective in treating amoebiasis. However Endemali has fewer side effects than MDF. New drugs need to be researched for the treatment of Entamoeba histolytica because of high failure rate of the two drugs against this killer organism.